Senior Manager, Clinical Operations - GI

Iterative Health is a healthcare technology and services company powering the acceleration of clinical research to transform patient outcomes.

We built a leading performance-driven network of 100+ sites across the US, Europe, India, and Australia, conducting research directly in the communities where care is delivered across gastrointestinal, hepatology, obesity, and cardiology. By combining deep clinical trial expertise with cutting-edge AI, we connect sponsors' scientific ambitions with high-performing research teams that expedite and expand access to novel therapeutics for patients in need. Today, Iterative Health is headquartered in Cambridge, Massachusetts, and New York City with 250+ employees world-wide.

As the Senior Manager, Clinical Operations- GI at Iterative Health you will serve as a strategic advisor to sponsors, CROs, and research sites, translating operational challenges into scalable solutions that improve study execution, accelerate activation timelines, and drive patient recruitment performance. By combining deep clinical research expertise with a consultative approach, this individual will help strengthen sponsor relationships, elevate site performance across the network, and contribute directly to Iterative Health's mission of bringing innovative therapies to patients faster.

As Iterative Health continues to expand its Site Network and partnerships with sponsors and CROs, operational excellence has become a critical differentiator. This role sits at the center of those relationships, helping ensure studies are launched efficiently, sites are set up for success, and sponsors receive the insights and partnership needed to achieve their clinical development goals. In particular, this role will own and scale the site activation process across the organization. This role is responsible for driving on-time site activations within SLAs, proactively identifying and resolving blockers, and improving activation workflows to increase speed, predictability, and efficiency.

This is a highly visible, customer-facing role with the opportunity to influence study strategy, shape operational best practices, and drive measurable impact across a growing portfolio of clinical trials.

Where You’ll Drive Impact 

Study Activation Ownership & Execution

Own the end-to-end site activations, managing timelines, dependencies, and risks across multiple concurrent sites and trials

Help teams prioritize tasks and ensure milestones are met within defined SLAs

Maintain activation plans, status tracking, and documentation, escalating risks and delays proactively

Sponsor & CRO Partnership

Serve as the primary operational partner to sponsors, CROs, and sites throughout the trial lifecycle

Lead and support sponsor, CRO, and partner meetings by providing clinical operations expertise, actionable insights, and strategic recommendations.

Build strong relationships with key stakeholders and ensure alignment on study goals, performance metrics, and operational priorities.

Proactively communicate study risks, mitigation plans, and escalation strategies

Facilitate educational sessions, webinars, and customer forums to strengthen engagement and share best practices.

Travel as needed to customer sites, investigator meetings, conferences, and sponsor engagements (up to 15%).

Study Performance & Operational Excellence

Monitor study performance metrics and own activation-specific reporting, including time-to-activation, SLA performance, and root causes of delays

Build and maintain dashboards that provide clear stakeholder visibility

Use data to inform prioritization, process improvements, and resourcing decisions

Identify operational gaps affecting site activation, enrollment, and execution, and collaborate cross-functionally to address them

Advocate for site needs and serve as a subject matter expert in clinical research operations

Collaborate cross-functionally to implement solutions t …